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Ozempic vs Wegovy in South Africa

How Ozempic (semaglutide) and Wegovy (semaglutide) compare on cost, dosing and what they're approved for.

	Ozempic	Wegovy
Active ingredient	semaglutide	semaglutide
How often	once weekly	once weekly
Monthly cost	R1 438–R3 225	R1 800–R3 700
Approved for	Registered in SA for type 2 diabetes; widely prescribed off-label for weight loss	Registered specifically for weight management (higher-dose semaglutide)
Medical aid	Generally not covered for weight loss	Not typically covered — obesity is not classified as a chronic condition by most SA schemes

Ozempic

The original semaglutide pen and the most recognised name in the category. Doses titrate from 0.25 mg up to 2 mg weekly — the 2 mg maintenance dose can run to roughly R6 000/month. Cheaper generic semaglutide is now starting to enter the SA market.

Ozempic details

Wegovy

Same active ingredient as Ozempic (semaglutide) but dosed and registered for weight loss, titrating up to 2.4 mg weekly. Novo Nordisk recently cut its SA prices, making the starting doses more competitive.

Wegovy details

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FAQ

Frequently asked questions

Is Ozempic or Wegovy better for weight loss?

Both can support weight loss, but suitability is individual. Ozempic uses semaglutide and Wegovy uses semaglutide. Your doctor will recommend based on your health and goals.

What is the price difference between Ozempic and Wegovy in South Africa?

Ozempic is indicatively R1 438–R3 225 a month, while Wegovy is R1 800–R3 700. Confirm current pharmacy prices.

Can I switch from Ozempic to Wegovy?

Only under medical supervision. A doctor will manage the change in dose and timing safely.

Sources: South African Health Products Regulatory Authority (SAHPRA) registration data, the approved package inserts, and public pharmacy price listings. Last reviewed 2026-05-30. No information here is medical advice.