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Ozempic vs Wegovy vs Mounjaro vs Saxenda
A plain side-by-side of the four weight-loss injections available in South Africa — on ingredient, dosing, cost and medical-aid cover.
| Ozempic | Wegovy | Mounjaro | Saxenda | |
|---|---|---|---|---|
| Active ingredient | semaglutide | semaglutide | tirzepatide | liraglutide |
| How often | once weekly | once weekly | once weekly | once daily |
| Monthly cost | R1 438–R3 225 | R1 800–R3 700 | R2 800–R5 500 | R2 800–R5 400 |
| Medical aid | Generally not covered for weight loss | Not typically covered — obesity is not classified as a chronic condition by most SA schemes | Generally not covered for weight loss; diabetes use may qualify on application | Not typically covered for weight loss |
| Details | Ozempic → | Wegovy → | Mounjaro → | Saxenda → |
Which is appropriate for you is a clinical decision. Discuss it with a doctor.
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Frequently asked questions
What is the best weight loss injection in South Africa?
There is no single best — it depends on your health, goals and budget. Mounjaro (tirzepatide) and Wegovy (semaglutide) are the newest weight-loss-focused options; your doctor will advise.
Which is cheapest?
At maintenance doses they are broadly similar. Mounjaro's lowest-dose pens are the cheapest entry point. See the prices page for current figures.
Are they all once a week?
Ozempic, Wegovy and Mounjaro are weekly. Saxenda (liraglutide) is a daily injection.
Sources: South African Health Products Regulatory Authority (SAHPRA) registration data, the approved package inserts, and public pharmacy price listings. Last reviewed 2026-05-30. No information here is medical advice.