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Ozempic vs Saxenda in South Africa

How Ozempic (semaglutide) and Saxenda (liraglutide) compare on cost, dosing and what they're approved for.

	Ozempic	Saxenda
Active ingredient	semaglutide	liraglutide
How often	once weekly	once daily
Monthly cost	R1 438–R3 225	R2 800–R5 400
Approved for	Registered in SA for type 2 diabetes; widely prescribed off-label for weight loss	Registered for weight management
Medical aid	Generally not covered for weight loss	Not typically covered for weight loss

Ozempic

The original semaglutide pen and the most recognised name in the category. Doses titrate from 0.25 mg up to 2 mg weekly — the 2 mg maintenance dose can run to roughly R6 000/month. Cheaper generic semaglutide is now starting to enter the SA market.

Ozempic details

Saxenda

The daily liraglutide pen — the longest-available weight-loss GLP-1 in SA, now often overtaken by weekly options. A 6 mg/mL pen is around R2 727, and a typical month works out near R4 600.

Saxenda details

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FAQ

Frequently asked questions

Is Ozempic or Saxenda better for weight loss?

Both can support weight loss, but suitability is individual. Ozempic uses semaglutide and Saxenda uses liraglutide. Your doctor will recommend based on your health and goals.

What is the price difference between Ozempic and Saxenda in South Africa?

Ozempic is indicatively R1 438–R3 225 a month, while Saxenda is R2 800–R5 400. Confirm current pharmacy prices.

Can I switch from Ozempic to Saxenda?

Only under medical supervision. A doctor will manage the change in dose and timing safely.

Sources: South African Health Products Regulatory Authority (SAHPRA) registration data, the approved package inserts, and public pharmacy price listings. Last reviewed 2026-05-30. No information here is medical advice.