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Ozempic vs Mounjaro in South Africa

How Ozempic (semaglutide) and Mounjaro (tirzepatide) compare on cost, dosing and what they're approved for.

	Ozempic	Mounjaro
Active ingredient	semaglutide	tirzepatide
How often	once weekly	once weekly
Monthly cost	R1 438–R3 225	R2 800–R5 500
Approved for	Registered in SA for type 2 diabetes; widely prescribed off-label for weight loss	Dual-action (GIP/GLP-1) for type 2 diabetes and weight management
Medical aid	Generally not covered for weight loss	Generally not covered for weight loss; diabetes use may qualify on application

Ozempic

The original semaglutide pen and the most recognised name in the category. Doses titrate from 0.25 mg up to 2 mg weekly — the 2 mg maintenance dose can run to roughly R6 000/month. Cheaper generic semaglutide is now starting to enter the SA market.

Ozempic details

Mounjaro

The newer tirzepatide option, often cited for strong results. Distributed by Aspen in SA as single-dose vials (a KwikPen is under SAHPRA evaluation); a typical month is about R4 000 for four vials.

Mounjaro details

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FAQ

Frequently asked questions

Is Ozempic or Mounjaro better for weight loss?

Both can support weight loss, but suitability is individual. Ozempic uses semaglutide and Mounjaro uses tirzepatide. Your doctor will recommend based on your health and goals.

What is the price difference between Ozempic and Mounjaro in South Africa?

Ozempic is indicatively R1 438–R3 225 a month, while Mounjaro is R2 800–R5 500. Confirm current pharmacy prices.

Can I switch from Ozempic to Mounjaro?

Only under medical supervision. A doctor will manage the change in dose and timing safely.

Sources: South African Health Products Regulatory Authority (SAHPRA) registration data, the approved package inserts, and public pharmacy price listings. Last reviewed 2026-05-30. No information here is medical advice.